ResearchLine™ Bioreactor

The ResearchLine™ Bioreactor is an advanced system designed for dynamic cell culture and in vitro incubation of tissue models and bionic organ constructs. The device supports three-dimensional constructs equipped with perfusion systems, enabling evaluation of cell viability and functionality under physiologically relevant conditions.

The system allows precise control of physicochemical parameters (temperature, flow rate, gas concentration) and enables testing of biological responses to bioactive substances and chemical compounds introduced into the culture medium. Automated monitoring and regulation ensure process standardization and high reproducibility of culture conditions.

Description

System Architecture

The bioreactor consists of two complementary modules:

  • Main Control Unit — Responsible for power supply and control of all system functions (media delivery, gas supply, sensor management). Equipped with an intuitive touchscreen control panel.
  • Sterile Single-Use Perfusion Set — Includes a sealed culture chamber, reservoirs, tubing, and connectors, enabling safe and reproducible culture processes and testing workflows.
Types of Research Chambers

The bioreactor includes two dedicated chamber types:

  • Bionic Organ Incubation Chamber — Stabilizes constructs and enables both biological and mechanical testing
  • Cytotoxicity and Bioactivity Testing Chamber — Allows parallel testing of up to three tissue models
Key Functions
  • Temperature control range: 8–40 °C
  • CO₂ concentration regulation and monitoring
  • Controlled perfusion flow rates
  • Automated cell culture media exchange
  • Sterile, non-invasive sampling
  • Perfusion system pressure control to protect tissue models from mechanical damage
Specifications
  • Power Supply: 110–240 V (±10%), 50/60 Hz
  • Operating Mode: Automatic
  • Environmental Operating Conditions:
     Temperature: +4 °C to +40 °C
     Humidity: 20–90%
     Pressure: 700–1060 hPa
  • Dimensions & Weight:
     Device: 70.9 × 49.6 × 33.8 cm, 35 kg
     Packaging: 80 × 60 × 40 cm
  • Cell Culture Media Exchange System: Sterility maintained during media replacement
  • Chamber Types: One for bionic organ culture; one for toxicity and bioactivity testing
  • Compatibility: Cell cultures, spheroids, organoids, and microorganisms