Biomaterials – Polbionica https://polbionica.com Thu, 30 Apr 2026 16:26:19 +0000 en-US hourly 1 https://wordpress.org/?v=6.9.4 https://polbionica.com/wp-content/uploads/2024/04/cropped-polbionica_sygnet-32x32.png Biomaterials – Polbionica https://polbionica.com 32 32 CleanCure™ CYX https://polbionica.com/produkt/cleancure-cyx/ Mon, 16 Mar 2026 17:11:25 +0000 https://polbionica.com/produkt/cleancure-cyx/ Hybrid module • Soft-to-mid mechanical profile • Dose-dependent performance CleanCure™ CYX is a hybrid module within the CleanCure™ platform based on gelatin functionalized with cinnamate groups. It is engineered to produce soft-to-mid stiffness hydrogels when combined with the active core component, CleanCure™ CM3X. Under 365 nm exposure, CYX does not provide an immediate mechanical reinforcement effect; instead, it offers a response profile that is highly dependent on exposure dose and illumination window — a key advantage for precision patterning and fine process control. In practical applications, CYX is well suited for engineering microenvironments where softness, gentle three-dimensional support, and controlled processing are prioritized over maximum stiffness. It is particularly valuable for epithelial and mucosal tissue models, where excessive mechanical rigidity may be undesirable.]]>

Key Features:

  • Soft-to-mid mechanical profile under tested 365 nm conditions
  • Mechanical behavior strongly dependent on exposure dose and illumination parameters
  • Well suited for soft, biomimetic 3D microenvironments
  • Designed for photoinitiator-free systems (in combination with CM3X)

Applications (Best For):

  • Epithelial and mucosal tissue models; soft ECM-mimicking environments
  • Photopatterning and applications requiring precise process windows and exposure control

Compatibility (Photoinitiator-Free Systems):

  • Designed for hybrid formulations with CM3X as the active core component

Mechanical Performance (Maximum G′, 365 nm)

System

60 s max G’ (Pa)

360 s max G’ (Pa)

CM + CYX

1018–1858 (median ~1566)

3728–6125 (median ~4190)

Safety & Handling

  • Use appropriate personal protective equipment (PPE); protect from UV exposure
  • Maintain aseptic conditions when working with cell-based systems

Shelf Life & Storage

  • Store tightly sealed and protected from light
  • Storage temperature and expiration date: to be specified based on QC validation
]]> CleanCure™ PA4X https://polbionica.com/produkt/cleancure-pa4x/ Mon, 16 Mar 2026 17:05:08 +0000 https://polbionica.com/?post_type=product&p=16304 Hybrid module • Mid-range mechanical profile CleanCure™ PNX is an aliphatic hybrid module (pentene-functionalized) engineered to produce hydrogels with a mid-range mechanical profile when formulated with the active core component, CleanCure™ CM3X. Compared to aromatic hybrid partners, PNX delivers robust final mechanical performance while providing a more compliant network structure — all while maintaining photoinitiator-free operation. In practical applications, PNX is an excellent choice when a material is required to maintain structural integrity without reaching the highest stiffness ranges. This mechanical profile is particularly advantageous for biological models where excessive rigidity may restrict cellular behavior or limit microenvironment remodeling.]]>

Key Features:

  • Stable mid-range mechanical profile in hybrid systems with CM3X
  • More compliant network architecture for improved biomimetic performance
  • Easy property tuning via exposure time, dosage, and formulation parameters
  • Designed for photoinitiator-free systems

Applications (Best for):

  • Soft stromal matrices and 3D cellular microenvironments with moderate stability
  • Tissue models requiring balanced performance: flexibility combined with construct integrity

Compatibility:

  • Designed for hybrid formulations with CM3X
  • Final performance parameters depend on overall formulation variables (concentration, temperature, medium composition)

Mechanical Performance (Maximum G′, 365 nm)

System60 s max G’ (Pa)360 s max G’ (Pa)
CM3X + PNX1244–3221 (median ~2439)5752–6313 (median ~6310)

Safety & Handling

  • Use appropriate personal protective equipment (PPE); protect from UV exposure
  • Maintain aseptic conditions when handling materials for cell-based applications

Shelf Life & Storage

  • Store tightly sealed and protected from light
  • Storage temperature and expiration date: to be specified based on QC validation
]]> CleanCure™ CM6X https://polbionica.com/produkt/cleancure-cm6x/ Mon, 16 Mar 2026 17:01:11 +0000 https://polbionica.com/produkt/cleancure-cm6x/ Hybrid module • Mid-to-high stiffness profile • Predictable modulus plateau CleanCure™ CM6X is a coumarin-based hybrid module designed for engineering hydrogels with a mid-to-high mechanical profile when combined with the active core component, CleanCure™ CM3X. Under tested conditions, CM6X enables a pronounced increase in mechanical modulus during light exposure while maintaining a more balanced performance compared to the VBX variant — without requiring photoinitiators. In practical applications, CM6X is well suited for scenarios requiring predictable mechanical behavior and construct stability without reaching maximum stiffness. It is an optimal choice for formulations where a careful balance is needed between geometric stability and biologically favorable conditions for sensitive cellular models.]]>

Key Features:

  • Mid-to-high stiffness profile (positioned between soft variants and VBX-reinforced systems)
  • Stable mechanical plateau achieved during extended light exposure
  • Balanced performance: construct stability without excessive brittleness (in hybrid systems with CM3X)

Applications (Best for):

  • Soft tissue models requiring moderate structural stability, such as liver and kidney tissue analogs (ECM-mimicking environments)
  • Complex 3D constructs with fine features and microchannels where reproducibility and dimensional stability are critical

Mechanical Performance (Maximum G′, 365 nm)

System

60 s max G’ (Pa)

360 s max G’ (Pa)

CM3X + CM6X

1498–3090 (median ~2110)

6227–7549 (median ~6794)

Safety & Handling

  • Use appropriate personal protective equipment (PPE); protect from UV exposure
  • Apply aseptic techniques for cell-based applications

Shelf Life & Storage

  • Store tightly sealed and protected from light
  • Storage temperature and expiration date: to be specified based on QC validation
]]> CleanCure™ VB4X https://polbionica.com/produkt/cleancure-vb4x/ Mon, 16 Mar 2026 15:04:45 +0000 https://polbionica.com/produkt/cleancure-vbx/ Hybrid module • Maximum stiffness • Rapid G’ build-up CleanCure™ VBX is a hybrid module within the CleanCure™ platform based on gelatin functionalized with vinylbenzoate groups. It is engineered to function as a performance partner for CleanCure™ CM3X, providing the highest efficiency in converting light energy into robust network formation under tested conditions — while maintaining photoinitiator-free operation. In practice, VBX acts as a mechanical performance booster, enabling rapid development of early-stage mechanical strength and achieving a high storage modulus (G′) plateau. This makes it particularly valuable in applications requiring excellent geometric stability, resistance to deformation, and precise feature retention, such as constructs with microchannels or thin-walled architectures.]]>

Key Features:

  • Highest G′ values within the product family (in hybrid formulations with CM3X)
  • Rapid storage modulus build-up from the earliest stages of light exposure
  • Excellent geometric stability and superior shape fidelity
  • Designed for photoinitiator-free operation

Applications (Best for):

  • Tissue reconstruction and models requiring stable geometry, including skin/dermis substitutes and load-bearing scaffolds
  • Stroma-rich tissue models and structural components in complex in vitro constructs
  • Perfusable microchannel systems and high-detail architectures

Compatibility (Photoinitiator-Free Systems):

  • Designed for hybridization with CM3X as the active core component

Mechanical Performance (Maximum G′, 365 nm)

System60 s max G’ (Pa)360 s max G’ (Pa)
CM3X + VBX3046–4721 (median ~3512)9462–10997 (median ~10382)

Safety & Handling

  • For research and development use only; wear appropriate personal protective equipment (gloves and safety glasses)
  • Protect from UV exposure; preparation and dispensing should be performed under reduced-light conditions
  • Use aseptic techniques for cell-based applications

Shelf Life & Storage

  • Store tightly sealed and protected from light
  • Storage temperature and expiration date: to be specified based on QC validation
]]> CleanCure™ CM3X https://polbionica.com/produkt/cleancure-cm3x/ Mon, 16 Mar 2026 14:54:50 +0000 https://polbionica.com/produkt/cleancure-cm3x/ Active core of the platform • 365 nm activation • Photoinitiator-free crosslinking CleanCure™ CM3X is the foundational component of the CleanCure™ series, designed as the active core of a light-activated hydrogel platform operating at 365 nm. CM3X is a gelatin derivative functionalized with coumaric acid (coumarin-3), which absorbs UV light, transitions into an excited state, and initiates localized crosslinking through a [2+2] photocycloaddition mechanism — without the need for photoinitiators. In practice, CM3X functions as a chromophore-as-linker system: it captures photons and redirects their energy into crosslinking reactions. This enables high spatial selectivity (curing restricted to illuminated regions) and supports the design of hybrid formulations enriched with CleanCure™ functional additives. CM3X serves as a versatile base for developing materials with programmable stiffness, viscosity, and gelation dynamics depending on the selected hybrid module.]]>
Key Features:
  • Activation at 365 nm with precise spatial control of curing
  • Modular system: mechanical properties tuned via VBX / CM6X / PNX / CYX selection
  • Gelatin-based (ECM-mimicking) platform for engineering 3D cellular microenvironments
  • Designed for photoinitiator-free operation
Applications (Best for):
  • Photopatterning and 3D photocuring (DLP / SLA) for stable 3D constructs
  • Soft tissue models, scaffolds, and research-grade hydrogels for R&D applications
Compatibility:
  • Active core component for hybrid systems with: VBX, CM6X, PNX, CYX
  • Compatible with standard laboratory buffers and cell culture media (final parameters formulation-dependent)
Safety & Handling
  • For research and development use only
  • Wear protective gloves and safety glasses during handling
  • Protect from light exposure (especially UV) during preparation and processing
  • For cell-based applications: prepare under aseptic conditions
Shelf Life & Storage
  • Store tightly sealed and protected from light
  • Storage temperature and expiration date: to be specified based on QC validation
]]> p-SE17® https://polbionica.com/produkt/p-se17/ Mon, 24 Jun 2024 14:30:29 +0000 https://polbionica.com/?post_type=product&p=15293 We invite you to explore our scientific publication: Cecuda-Adamczewska, V.; Romanik-Chruścielewska, A.; Kosowska, K.; Sokołowska, I.; Łukasiewicz, N.; Korycka, P.; Florys-Jankowska, K.; Zakrzewska, A.; Wszoła, M.; Klak, M. Elasticity Modification of Biomaterials Used in 3D Printing with an Elastin–Silk-like Recombinant Protein. J. Funct. Biomater. 2024, 15, 141. https://doi.org/10.3390/jfb15060141        ]]>

Strategic combinations of RGD adhesion domains and ZIP structural motifs provide enhanced structural stability while simultaneously creating a favorable microenvironment for cell growth. This unique molecular design promotes efficient cell adhesion and proliferation.

 

p-SE17® is produced in a prokaryotic expression system and purified without detergents or surfactants, ensuring excellent biocompatibility for applications in 3D bioprinting and biofabrication. It can serve as a functional bioink additive or as an alternative to conventional biomaterials used in tissue engineering.

 

 

 

  • Przechowywanie: 2-10 °C
  • Opakowanie: 1g
]]> p-RE15® https://polbionica.com/produkt/p-re15/ Mon, 24 Jun 2024 14:19:22 +0000 https://polbionica.com/?post_type=product&p=15297 We invite you to explore our scientific publication: Cecuda-Adamczewska, V.; Romanik-Chruścielewska, A.; Kosowska, K.; Łukasiewicz, N.; Sokołowska, I.; Korycka, P.; Florys-Jankowska, K.; Zakrzewska, A.; Wszoła, M.; Klak, M. Characterization of a Chimeric Resilin-Elastin Structural Protein Dedicated to 3D Bioprinting as a Bioink Component. Nanomaterials 2024, 14, 749. https://doi.org/10.3390/nano14090749 ]]>

Thanks to its biomimetic architecture, p-RE15® creates a favorable microenvironment for eukaryotic cell growth, supporting efficient cell colonization, migration, and proliferation.

 

As a functional component, p-RE15® significantly enhances the rheological performance and mechanical strength of enriched biomaterials, improving their suitability for advanced bioengineering applications.

 

p-RE15® is produced in a prokaryotic expression system and purified without the use of detergents or surfactants, making it a highly biocompatible component for 3D bioprinting and biofabrication. It can be used as a functional additive to bioinks or as an alternative to conventional biomaterials used in tissue engineering.

 

 

 

  • Przechowywanie: 2-10 °C
  • Opakowanie: 1g
]]> Tintbionic® GELMA 50 https://polbionica.com/produkt/tintbionic-gelma-50/ Fri, 17 May 2024 15:09:49 +0000 https://polbionica.esc2.emartsynergia.com/produkt/tintbionic-gelma-50/

Key Features

  • Methacrylated gelatin base for bioinks and hydrogels in 3D bioprinting
  • Pharmaceutical-grade raw material: porcine gelatin (300° Bloom) from a certified Polish source
  • Enables tunable material properties through formulation and process parameter control
  • Compatible with standard UV/Vis photocuring protocols in the presence of photoinitiators (e.g., LAP)

Applications

  • 3D soft tissue models and cell-laden constructs for in vitro research
  • Photocuring in layer-by-layer fabrication techniques (DLP / SLA) and photopatterning workflows
  • Base component for blends with other methacrylate-functionalized materials in R&D formulation development

Downloads:

SDS
]]> Tintbionic® GELMA 80 https://polbionica.com/produkt/tintbionic-gelma-80/ Fri, 17 May 2024 15:08:05 +0000 https://polbionica.esc2.emartsynergia.com/produkt/tintbionic-gelma-80/ TintBionic® GELMA 80 is a methacrylated gelatin variant engineered for applications where enhanced construct stability and geometric fidelity are critical during fabrication and subsequent material handling. The product is based on pharmaceutical-grade porcine gelatin with a Bloom strength of 300°, sourced from a controlled and certified supplier, ensuring consistent material performance across production batches. This material is designed for the formulation of photocurable hydrogels, particularly for constructs with complex geometries, thin walls, or channel-like architectures. Crosslinking occurs under UV/Vis light exposure in the presence of a photoinitiator (e.g., LAP), while the final hydrogel characteristics depend on the complete formulation and process conditions.]]>

Key Features

  • Variant optimized for improved shape stability and geometric fidelity
  • Pharmaceutical-grade raw material: porcine gelatin (300° Bloom) from a certified Polish supplier
  • Compatible with UV/Vis photocuring protocols in the presence of photoinitiators (e.g., LAP)
  • Suitable as a base for methacrylate-based blends designed to produce structurally stable constructs

Applications

  • 3D constructs with high geometric precision requirements (fine details, thin walls, channel structures)
  • Scaffolds and hydrogels for projects where construct stability is a critical performance parameter
  • R&D projects focused on developing materials with enhanced load-bearing capacity for soft tissue engineering

Downloads:

SDS
]]> Tintbionic® ALGMA https://polbionica.com/produkt/tintbionic-algma/ Fri, 17 May 2024 15:07:57 +0000 https://polbionica.esc2.emartsynergia.com/produkt/tintbionic-algma/ TintBionic® ALGMA is a methacrylated sodium alginate derivative developed for applications in biofabrication and tissue reconstruction. Alginate introduces a polysaccharide-based character to material formulations and contributes beneficial properties resulting from its widespread use in biomedical applications. The material is available in viscosity-graded variants, allowing precise selection based on process requirements, including solution preparation parameters and mixture behavior during bioprinting. ALGMA is particularly valuable as a component of multicomponent methacrylate-based formulations, where alginate functions as a performance-modulating ingredient that shapes the rheological and handling properties of the bioink.]]>

Key Features

  • Methacrylated alginate serving as a polysaccharide component for 3D bioinks and hydrogels
  • Viscosity-tailored variants enabling selection according to process and solution preparation requirements
  • Designed for multicomponent formulations where alginate modulates mixture performance
  • UV/Vis photocuring compatibility in the presence of photoinitiators (e.g., LAP), depending on the complete formulation

Applications

  • Multicomponent bioink formulations where viscosity control and process behavior are critical parameters
  • 3D hydrogels for tissue reconstruction within composite biomaterial systems
  • Formulations requiring a polysaccharide component with controlled viscosity

Downloads:

SDS
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