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	<title>CleanCure™ &#8211; Polbionica</title>
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	<link>https://polbionica.com</link>
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	<title>CleanCure™ &#8211; Polbionica</title>
	<link>https://polbionica.com</link>
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	<item>
		<title>CleanCure™ CYX</title>
		<link>https://polbionica.com/produkt/cleancure-cyx/</link>
		
		<dc:creator><![CDATA[admin]]></dc:creator>
		<pubDate>Mon, 16 Mar 2026 17:11:25 +0000</pubDate>
				<guid isPermaLink="false">https://polbionica.com/produkt/cleancure-cyx/</guid>

					<description><![CDATA[<strong>Hybrid module • Soft-to-mid mechanical profile • Dose-dependent performance</strong>

CleanCure™ CYX is a hybrid module within the CleanCure™ platform based on gelatin functionalized with cinnamate groups. It is engineered to produce soft-to-mid stiffness hydrogels when combined with the active core component, CleanCure™ CM3X. Under 365 nm exposure, CYX does not provide an immediate mechanical reinforcement effect; instead, it offers a response profile that is highly dependent on exposure dose and illumination window — a key advantage for precision patterning and fine process control.

In practical applications, CYX is well suited for engineering microenvironments where softness, gentle three-dimensional support, and controlled processing are prioritized over maximum stiffness. It is particularly valuable for epithelial and mucosal tissue models, where excessive mechanical rigidity may be undesirable.]]></description>
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									<p><strong>Key Features:</strong></p><ul><li>Soft-to-mid mechanical profile under tested 365 nm conditions</li><li>Mechanical behavior strongly dependent on exposure dose and illumination parameters</li><li>Well suited for soft, biomimetic 3D microenvironments</li><li>Designed for photoinitiator-free systems (in combination with CM3X)</li></ul><p><strong>Applications (Best For):</strong></p><ul><li>Epithelial and mucosal tissue models; soft ECM-mimicking environments</li><li>Photopatterning and applications requiring precise process windows and exposure control</li></ul><p><strong>Compatibility (Photoinitiator-Free Systems):</strong></p><ul><li>Designed for hybrid formulations with CM3X as the active core component</li></ul><p><strong>Mechanical Performance (Maximum G′, 365 nm)</strong></p><table><tbody><tr><td><p><strong>System</strong></p></td><td><p><strong>60 s max G’ (Pa)</strong></p></td><td><p><strong>360 s max G’ (Pa)</strong></p></td></tr><tr><td><p>CM + CYX</p></td><td><p>1018–1858 (median ~1566)</p></td><td><p>3728–6125 (median ~4190)</p></td></tr></tbody></table><p><strong>Safety &amp; Handling</strong></p><ul><li>Use appropriate personal protective equipment (PPE); protect from UV exposure</li><li>Maintain aseptic conditions when working with cell-based systems</li></ul><p><strong>Shelf Life &amp; Storage</strong></p><ul><li>Store tightly sealed and protected from light</li><li>Storage temperature and expiration date: to be specified based on QC validation</li></ul>								</div>
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		<title>CleanCure™ PA4X</title>
		<link>https://polbionica.com/produkt/cleancure-pa4x/</link>
		
		<dc:creator><![CDATA[admin]]></dc:creator>
		<pubDate>Mon, 16 Mar 2026 17:05:08 +0000</pubDate>
				<guid isPermaLink="false">https://polbionica.com/?post_type=product&#038;p=16304</guid>

					<description><![CDATA[<strong>Hybrid module • Mid-range mechanical profile</strong>

CleanCure™ PNX is an aliphatic hybrid module (pentene-functionalized) engineered to produce hydrogels with a mid-range mechanical profile when formulated with the active core component, CleanCure™ CM3X. Compared to aromatic hybrid partners, PNX delivers robust final mechanical performance while providing a more compliant network structure — all while maintaining photoinitiator-free operation.

In practical applications, PNX is an excellent choice when a material is required to maintain structural integrity without reaching the highest stiffness ranges. This mechanical profile is particularly advantageous for biological models where excessive rigidity may restrict cellular behavior or limit microenvironment remodeling.]]></description>
										<content:encoded><![CDATA[		<div data-elementor-type="wp-post" data-elementor-id="16304" class="elementor elementor-16304">
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									<p><strong>Key Features:</strong></p><ul><li>Stable mid-range mechanical profile in hybrid systems with CM3X</li><li>More compliant network architecture for improved biomimetic performance</li><li>Easy property tuning via exposure time, dosage, and formulation parameters</li><li>Designed for photoinitiator-free systems</li></ul><p><strong>Applications (Best for):</strong></p><ul><li>Soft stromal matrices and 3D cellular microenvironments with moderate stability</li><li>Tissue models requiring balanced performance: flexibility combined with construct integrity</li></ul><p><strong>Compatibility:</strong></p><ul><li>Designed for hybrid formulations with CM3X</li><li>Final performance parameters depend on overall formulation variables (concentration, temperature, medium composition)</li></ul><p><strong>Mechanical Performance (Maximum G′, 365 nm)</strong></p><table><tbody><tr><td><strong>System</strong></td><td><strong>60 s max G’ (Pa)</strong></td><td><strong>360 s max G’ (Pa)</strong></td></tr><tr><td>CM3X + PNX</td><td>1244–3221 (median ~2439)</td><td>5752–6313 (median ~6310)</td></tr></tbody></table><p><strong>Safety &amp; Handling</strong></p><ul><li>Use appropriate personal protective equipment (PPE); protect from UV exposure</li><li>Maintain aseptic conditions when handling materials for cell-based applications</li></ul><p><strong>Shelf Life &amp; Storage</strong></p><ul><li>Store tightly sealed and protected from light</li><li>Storage temperature and expiration date: to be specified based on QC validation</li></ul>								</div>
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		<title>CleanCure™ CM6X</title>
		<link>https://polbionica.com/produkt/cleancure-cm6x/</link>
		
		<dc:creator><![CDATA[admin]]></dc:creator>
		<pubDate>Mon, 16 Mar 2026 17:01:11 +0000</pubDate>
				<guid isPermaLink="false">https://polbionica.com/produkt/cleancure-cm6x/</guid>

					<description><![CDATA[<strong>Hybrid module • Mid-to-high stiffness profile • Predictable modulus plateau</strong>

CleanCure™ CM6X is a coumarin-based hybrid module designed for engineering hydrogels with a mid-to-high mechanical profile when combined with the active core component, CleanCure™ CM3X. Under tested conditions, CM6X enables a pronounced increase in mechanical modulus during light exposure while maintaining a more balanced performance compared to the VBX variant — without requiring photoinitiators.

In practical applications, CM6X is well suited for scenarios requiring predictable mechanical behavior and construct stability without reaching maximum stiffness. It is an optimal choice for formulations where a careful balance is needed between geometric stability and biologically favorable conditions for sensitive cellular models.]]></description>
										<content:encoded><![CDATA[		<div data-elementor-type="wp-post" data-elementor-id="16299" class="elementor elementor-16299 elementor-16294">
						<section class="elementor-section elementor-top-section elementor-element elementor-element-53b3221 elementor-section-full_width elementor-section-height-default elementor-section-height-default" data-id="53b3221" data-element_type="section" data-e-type="section">
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									<p><strong>Key Features:</strong></p><ul><li>Mid-to-high stiffness profile (positioned between soft variants and VBX-reinforced systems)</li><li>Stable mechanical plateau achieved during extended light exposure</li><li>Balanced performance: construct stability without excessive brittleness (in hybrid systems with CM3X)</li></ul><p><strong>Applications (Best for):</strong></p><ul><li>Soft tissue models requiring moderate structural stability, such as liver and kidney tissue analogs (ECM-mimicking environments)</li><li>Complex 3D constructs with fine features and microchannels where reproducibility and dimensional stability are critical</li></ul><p><strong>Mechanical Performance (Maximum G′, 365 nm)</strong></p><table><tbody><tr><td><p><strong>System</strong></p></td><td><p><strong>60 s max G’ (Pa)</strong></p></td><td><p><strong>360 s max G’ (Pa)</strong></p></td></tr><tr><td><p>CM3X + CM6X</p></td><td><p>1498–3090 (median ~2110)</p></td><td><p>6227–7549 (median ~6794)</p></td></tr></tbody></table><p><strong>Safety &amp; Handling</strong></p><ul><li>Use appropriate personal protective equipment (PPE); protect from UV exposure</li><li>Apply aseptic techniques for cell-based applications</li></ul><p><strong>Shelf Life &amp; Storage</strong></p><ul><li>Store tightly sealed and protected from light</li><li>Storage temperature and expiration date: to be specified based on QC validation</li></ul>								</div>
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		<title>CleanCure™ VB4X</title>
		<link>https://polbionica.com/produkt/cleancure-vb4x/</link>
		
		<dc:creator><![CDATA[admin]]></dc:creator>
		<pubDate>Mon, 16 Mar 2026 15:04:45 +0000</pubDate>
				<guid isPermaLink="false">https://polbionica.com/produkt/cleancure-vbx/</guid>

					<description><![CDATA[<strong>Hybrid module • Maximum stiffness • Rapid G’ build-up</strong>

CleanCure™ VBX is a hybrid module within the CleanCure™ platform based on gelatin functionalized with vinylbenzoate groups. It is engineered to function as a performance partner for CleanCure™ CM3X, providing the highest efficiency in converting light energy into robust network formation under tested conditions — while maintaining photoinitiator-free operation.

In practice, VBX acts as a mechanical performance booster, enabling rapid development of early-stage mechanical strength and achieving a high storage modulus (G′) plateau. This makes it particularly valuable in applications requiring excellent geometric stability, resistance to deformation, and precise feature retention, such as constructs with microchannels or thin-walled architectures.]]></description>
										<content:encoded><![CDATA[		<div data-elementor-type="wp-post" data-elementor-id="16279" class="elementor elementor-16279 elementor-16199">
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									<p><strong>Key Features:</strong></p><ul><li>Highest G′ values within the product family (in hybrid formulations with CM3X)</li><li>Rapid storage modulus build-up from the earliest stages of light exposure</li><li>Excellent geometric stability and superior shape fidelity</li><li>Designed for photoinitiator-free operation</li></ul><p><strong>Applications (Best for):</strong></p><ul><li>Tissue reconstruction and models requiring stable geometry, including skin/dermis substitutes and load-bearing scaffolds</li><li>Stroma-rich tissue models and structural components in complex in vitro constructs</li><li>Perfusable microchannel systems and high-detail architectures</li></ul><p><strong>Compatibility (Photoinitiator-Free Systems):</strong></p><ul><li>Designed for hybridization with CM3X as the active core component</li></ul><p><strong>Mechanical Performance (Maximum G′, 365 nm)</strong></p><table><tbody><tr><td><strong>System</strong></td><td><strong>60 s max G’ (Pa)</strong></td><td><strong>360 s max G’ (Pa)</strong></td></tr><tr><td>CM3X + VBX</td><td>3046–4721 (median ~3512)</td><td>9462–10997 (median ~10382)</td></tr></tbody></table><p><strong>Safety &amp; Handling</strong></p><ul><li>For research and development use only; wear appropriate personal protective equipment (gloves and safety glasses)</li><li>Protect from UV exposure; preparation and dispensing should be performed under reduced-light conditions</li><li>Use aseptic techniques for cell-based applications</li></ul><p><strong>Shelf Life &amp; Storage</strong></p><ul><li>Store tightly sealed and protected from light</li><li>Storage temperature and expiration date: to be specified based on QC validation</li></ul>								</div>
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		<title>CleanCure™ CM3X</title>
		<link>https://polbionica.com/produkt/cleancure-cm3x/</link>
		
		<dc:creator><![CDATA[admin]]></dc:creator>
		<pubDate>Mon, 16 Mar 2026 14:54:50 +0000</pubDate>
				<guid isPermaLink="false">https://polbionica.com/produkt/cleancure-cm3x/</guid>

					<description><![CDATA[<strong>Active core of the platform • 365 nm activation • Photoinitiator-free crosslinking</strong>

CleanCure™ CM3X is the foundational component of the CleanCure™ series, designed as the active core of a light-activated hydrogel platform operating at 365 nm. CM3X is a gelatin derivative functionalized with coumaric acid (coumarin-3), which absorbs UV light, transitions into an excited state, and initiates localized crosslinking through a [2+2] photocycloaddition mechanism — without the need for photoinitiators.

In practice, CM3X functions as a chromophore-as-linker system: it captures photons and redirects their energy into crosslinking reactions. This enables high spatial selectivity (curing restricted to illuminated regions) and supports the design of hybrid formulations enriched with CleanCure™ functional additives. CM3X serves as a versatile base for developing materials with programmable stiffness, viscosity, and gelation dynamics depending on the selected hybrid module.]]></description>
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									<strong>Key Features:</strong>
<ul>
 	<li>Activation at 365 nm with precise spatial control of curing</li>
 	<li>Modular system: mechanical properties tuned via VBX / CM6X / PNX / CYX selection</li>
 	<li>Gelatin-based (ECM-mimicking) platform for engineering 3D cellular microenvironments</li>
 	<li>Designed for photoinitiator-free operation</li>
</ul>

<strong>Applications (Best for):</strong>
<ul>
 	<li>Photopatterning and 3D photocuring (DLP / SLA) for stable 3D constructs</li>
 	<li>Soft tissue models, scaffolds, and research-grade hydrogels for R&amp;D applications</li>
</ul>

<strong>Compatibility:</strong>
<ul>
 	<li>Active core component for hybrid systems with: VBX, CM6X, PNX, CYX</li>
 	<li>Compatible with standard laboratory buffers and cell culture media (final parameters formulation-dependent)</li>
</ul>

<strong>Safety &amp; Handling</strong>
<ul>
 	<li>For research and development use only</li>
 	<li>Wear protective gloves and safety glasses during handling</li>
 	<li>Protect from light exposure (especially UV) during preparation and processing</li>
 	<li>For cell-based applications: prepare under aseptic conditions</li>
</ul>

<strong>Shelf Life &amp; Storage</strong>
<ul>
 	<li>Store tightly sealed and protected from light</li>
 	<li>Storage temperature and expiration date: to be specified based on QC validation</li>
</ul>								</div>
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