The organ culture bioreactor is a novel solution for maintaining vital organ parameters under normothermic conditions, developed entirely by the scientific team of the Foundation for Research and Science Development. Its role is to monitor and control the physicochemical parameters of the system during organ perfusion, including glycemia, oxygenation, temperature, velocity, and perfusion pressure. It also ensures the proper dosage of medications and nutrients. The system includes control and measuring equipment cooperating with several executive systems. The whole system is controlled by built-in digital circuits, which additionally enable remote monitoring and control of the perfusion process in real-time as well as acquisition and archiving of process data. Ultimately, the device is designed to provide appropriate physiological conditions for organs after the bioprinting process, but due to its flexibility, the bioreactor can also be used for other biomedical applications.