Assoc. Prof. Michał Wszoła MD, PhD
A transplant surgeon, dedicated physician and visionary scientist, he originator of the bionic pancreas – an organ that will restore the body’s ability to regulate blood sugar and revolutionise the treatment of diabetes. He has been running a medical practice for years, leading a team that conducts innovative research- on a global scale – and searches for innovative solutions in medicine. He participated in the first pancreatic islet transplant in Poland (2008), the first pancreas-only transplant (2010) and the first exchange of kidney pairs between family donors (2015). The combination of his passions, transplantology and endoscopy, led to the creation of a new method of treating diabetes – endoscopic transplantation of pancreatic islets under the gastric mucosa. In 2013, he performed first such procedure in the world, which is now used in several centres in the United States of America.
He is currently continuing to work on a 3D printing project of a bionic pancreas with a research team at the Foundation of Research and Science Development. Co-founder of the medical knowledge sharing portalwww.medtube.net and the medical app www.medizzy.com, bringing together over 400,000 doctors and medical students from around the world. Medical director of CM Medispace and CEO at Polbionica sp. z o.o.
FOUNDATION OF REASERCH AND SCIENCE DEVELOPMENT – Chairman of the Scientific Council of the Foundation
POLBIONICA SP. Z O. O. – CEO
MEDISPACE SP. Z. O. O. – Medical Director
Based on my years of experience as a transplant surgeon and my knowledge of the problems associated with the current treatment of diabetes, I created an unusual concept of printing a bionic pancreas. In a short period of time I was able to spread this idea to other doctors and scientists who believed in this project, which is unique on a global scale. Our shared goal is to develop a pioneering medical therapy that will revolutionise the treatment of diabetes.
Since 2017, the Foundation of Research and Science Development, as the leader of the Bionic Consortium, has been working on the implementation of the bionic pancreas project. After only 2 years of preparation and testing, we printed the world’s first vascularised bionic pancreas prototype measuring 3x3x5cm. The 14th of March 2019 is the day we proved to ourselves and the world that the impossible became possible and that tissue and organ bioprinting is the future of modern medicine that will change the lives of many patients.
We placed the printed organ in a bioreactor that feeds fluid with oxygen and nutrients into the vascular system. Further studies showed that pancreas produces insulin, and magnetic resonance imaging showed a faithful representation of the planned vascular system. Over the next six months, we worked on improving the bioreactor, perfusion fluid, and vascular system, and developed the technology to make external blood vessels. The results achieved allowed us to move to the next phase and begin animal studies.
Our mission is to bring 3D printing of the bionic pancreas into clinical practice worldwide. In order to do so, as well as to implement other innovative projects, we want to create the European Center of Medical Biotechnology. As the only such research and clinical centre in Poland, it will enable development of pioneering medical therapies. A direct connection between the world of science and medicine in one place will ensure faster and more effective implementation of the latest achievements into clinical practice. With your support, we want to create a space where scientists and doctors will develop innovative technologies to solve the most serious medical problems of the 21st century.
2020, 2019 Ambassador of Polish Science, nomination
2020 Congress of Electronic Economy and “Promyk Słońca” Foundation Award
2019 Winner of the “List of Hundred” contest
2019 Award of the 14th Congress of the Polish Transplantation Society
2018 Order of Distinction – American Transplant Congress in Seattle
2018 II Golden Scalpel Competition, Puls Medycyny [independent newspaper of professionals]
2016 Golden Cross of Merit awarded by President Andrzej Duda
2013 Gedeon Richter First Prize
2013 Polish Transplantation Society Award
2011 Award of the Videosurgery section of the Polish Surgeons Society
2010 Prime Minister Donald Tusk Award
2009 Bronze Cross of Merit awarded by the President of the Republic of Poland Lech Kaczyński
2009 First prize of RISET (Reprogramming Immune System toward Tolerance) Society
2009 Polish Transplantation Society Award
2008 Award of the Rector of the Medical University of Warsaw
2008 First Degree Team Award of the Rector of the Medical University of Warsaw
2008 Order of Distinction – American Transplant Congress, Montreal (Canada)
2007 European Transplantation Society Award
2007 Order of Distinction – American Transplant Congress, San Francisco (USA) 2002 Award of the Rector of the Medical University of Warsaw
2001 Belzer’s Award in Organ Preservation, Nagoya (Japan)
- Stem Cells as a Source of Pancreatic Cells for Production of 3D Bioprinted Bionic Pancreas in the Treatment of Type 1 Diabetes
Wszoła M, Nitarska D, Cywoniuk P, Gomółka M, Klak
MCells. 2021 Jun 18;10(6):1544. doi: 10.3390/cells10061544.
- Bionic Organs: Shear Forces Reduce Pancreatic Islet and Mammalian Cell Viability during the Process of 3D Bioprinting
Klak M, Kowalska P, Dobrzański T, Tymicki G, Cywoniuk P, Gomółka M, Kosowska K, Bryniarski T, Berman A, Dobrzyń A, Sadowski W, Górecki B, Wszoła M.
Micromachines (Basel). 2021 Mar 14;12(3):304. doi: 10.3390/mi12030304.
Klak M, Łojszczyk I, Berman A, Tymicki G, Adamiok-Ostrowska A, Sierakowski M, Olkowski R, Szczepankiewicz A, Kamiński A, Dobrzyń A, Wszoła M.
Int J Mol Sci. 2021 Jun 29;22(13):7005. doi: 10.3390/ijms22137005.
- Crosstalk Between Immunity System Cells and Pancreas. Transformation of Stem Cells Used in the 3D Bioprinting Process as a Personalized Treatment Method for Type 1 Diabetes.
Niedźwiedzka-Rystwej P, Wołącewicz M, Cywoniuk P, Klak M, Wszoła M.
Arch Immunol Ther Exp (Warsz). 2020 Apr 15;68(2):13. doi: 10.1007/s00005-020-00578-2
- The Influence of the Flow of Detergent and Donor Characteristics on the Extracellular Matrix Composition After Human Pancreas Decellularization.
Berman A, Klak M, Adamiok A, Kaczyński Ł, Tymicki G, Gomółka M, Kowalska P, Kosowska K, Cywoniuk P, Turowski P, Bryniarski T, Wyrwicki M, Olkowski R, Kamiński A, Wszoła M.
Transplant Proc. 2020 Sep;52(7):2043-2049. doi: 10.1016/j.transproceed.2020.03.053. Epub 2020 Jun 8.PMID: 32527472
Klak M, Gomółka M, Kowalska P, Cichoń J, Ambrożkiewicz F, Serwańska-Świętek M, Berman A, Wszoła M.
Cent Eur J Immunol. 2020;45(4):439-453. doi: 10.5114/ceji.2020.103386. Epub 2021 Feb 7.
Klak M, Bryniarski T, Kowalska P, Gomolka M, Tymicki G, Kosowska K, Cywoniuk P, Dobrzanski T, Turowski P, Wszola M.
Micromachines (Basel). 2020 Jun 30;11(7):646. doi: 10.3390/mi11070646.
- Irradiation with 365 nm and 405 nm wavelength shows differences in DNA damage of swine pancreatic islets.
Klak M, Gomółka M, Dobrzański T, Tymicki G, Cywoniuk P, Kowalska P, Kosowska K, Bryniarski T, Berman A, Dobrzyń A, Idaszek J, Święszkowski W, Wszoła M.
PLoS One. 2020 Jun 25;15(6):e0235052. doi: 10.1371/journal.pone.0235052.
Kwiatkowski A, Wszola M, Kosieradzki M, Danielewicz R, Ostrowski K, Domagala P, Lisik W, Nosek R, Fesolowicz S, Trzebicki J, Durlik M, Paczek L, Chmura A, Rowinski W.
Am J Transplant. 2007 Aug;7(8):1942-7. doi: 10.1111/j.1600-6143.2007.01877.x.
- The early and long term function and survival of kidney allografts stored before transplantation by hypothermic pulsatile perfusion. A prospective randomized study.
Kwiatkowski A, Wszoła M, Kosieradzki M, Danielewicz R, Ostrowski K, Domagala P, Lisik W, Fesołowicz S, Michalak G, Trzebicki J, Durlik M, Paczek L, Rowiński W, Chmura A.
Ann Transplant. 2009 Jan-Mar;14(1):14-7.
- Long term medical and economical benefit of machine perfusion (MP) kidney storage in comparison to cold storage (CS).
Wszola M, Kwiatkowski A, Latek M, Ostrowski K, Domagala P, Ciszek M, Trzebicki J, Durlik M, Chmura A, Rowinski W.
Ann Transplant. 2009 Apr-Jun;14(2):24-9.
Kwiatkowski A, Wszoła M, Perkowska-Ptasińska A, Ostrowski K, Domagała P, Fesołowicz S, Trzebicki J, Durlik M, Paczek L, Rowiński W, Chmura A.
Ann Transplant. 2009 Jan-Mar;14(1):10-3.
- One-year results of a prospective, randomized trial comparing two machine perfusion devices used for kidney preservation.
Wszola M, Kwiatkowski A, Diuwe P, Domagała P, Górski L, Kieszek R, Berman A, Perkowska-Ptasińska A, Durlik M, Pączek L, Chmura A.
Transpl Int. 2013 Nov;26(11):1088-96. doi: 10.1111/tri.12169. Epub 2013 Aug 27.
Wszoła M, Kwiatkowski A, Ostaszewska A, Górski L, Kuthan R, Sawicka-Grzelak A, Diuwe P, Góralski P, Drozdowski J, Kawecki D, Młynarczyk G, Chmura A.
Transplantation. 2013 Mar 27;95(6):878-82. doi: 10.1097/TP.0b013e318281b953.
- Preservation of kidneys by machine perfusion influences gene expression and may limit ischemia/reperfusion injury.
Wszola M, Kwiatkowski A, Domagala P, Wirkowska A, Bieniasz M, Diuwe P, Rafał K, Durlik M, Chmura A.
Prog Transplant. 2014 Mar;24(1):19-26. doi: 10.7182/pit2014384.